L tyrosine no effects reddit Nothing too eye-popping, but supplementing with a low dose of L-tyrosine in the mornings (2g) has significantly improved my wakefulness, and has reduced by need for caffeine quite a bit. 150mg/kg L-Tyrosine taken in a vessel of apple sauce can elevated plasma Tyrosine concentrations from 56. Mar 10, 2025 · In this review, we will take an in-depth look at L-Tyrosine, the benefits of L-Tyrosine, the best dosage, side effects, and reviews from other users on Reddit. Tryptophan has bad side effects too and am not a fan. I’m thinking about adding in L-theanine during the day to help take the edge off. 5 till 20 gram per day is often use We would like to show you a description here but the site won’t allow us. We also host challenges in which participants ("Fapstronauts") avoid porn & sometimes masturbation for a period of time, generally 7-30 days. Makes sense though. Researching these ingredients +adhd led me here, so I just wanted to say I actually felt the benefit of L-tyrosine & 5htp before knowing that they could even help adhd! 4. (All of this is regardless of whether that "pump Reason being L-Tyrosine converts to L-DOPA, which in turn shares the competes with 5-HTP at the AAAD enzyme for converting into their respective neurotransmitters. Oh btw, my diagnoses were considered manic, clinical depression, and tons of anxiety. So I had a weird experience there about 2 weeks ago, I had stopped taking my daily dose of L-Tyrosine 375mg every 2 days. It will be impossible to get this dopamine surge through real world activities. I get a pretty good buzz off a usual "make me not feel like crap" dose of caffeine, and can now go totally without stimulants and still feel pretty good. I've taken 500mg of L-tyrosine 3 times a week (or when needed) for 3 weeks. Google "Cheese Syndrome" for more information on that) but, honestly, I wouldn't put too much faith into L-tyrosine. L-Arginine was hyped up in the fitness supplement industry for so many years to be the thing that boosts your nitric oxide levels and gives you that pump in the gym, before L-Citrulline became a household name and people started talking about how it really does what L-Arginine was supposed to do. Everything you feel from it is placebo. I started to take L-Tyrosine yesterday among L-Theanine, D3/K2, coffee, B-Complex, Krill oil and magtein the night before. I made a video about my experience with it, you might find it helpful! Unless you are having a tyrosine deficiency it will not help. L-tyrosime → L-dopa → Dopamine. and on the days where take L-Tyrosine AND exercise, I have the focus and time management along with clear thinking of being on Concerta or Adderall, but without the Meth-Head feeling. Studies in humans showing most anti-stress promise for acute supplemental L-Tyrosine use a dosage range of 100-150mg/kg bodyweight which can be taken 60 minutes before exercise; this is a dosage range of 9-13. In your case, I’m sure you’ll benefit from it if you’re not not taking any stimulants (Caffeine doesn’t count). Immediately my anxiety dropped. Not even when injected. Bromantane upregulates Tyrosine hydroxylase, which is the main explanation for its stimulant effects. See full list on health. Aaaaand well 4 hours of kind of being high, well, not high exactly but definitely elevated. I’ve tried NAL-Tyrosine and it was not as effective as regular tyrosine If you go the tyrosine route and it's not working you can try N-acetyl-L-tyrosine. Melanin reduces sun damage, but melanoma is cancer in melanocytes. It isn't like there is a limiting amount of tyrosine in the body so there isn't any real reason for the body to not be making the amount of dopamine that it needs. clevelandclinic. Unfortunately, Sudafed or pseudoephedrine also causes insomnia. I've now taken 3g L-Tyrosine daily for 2 days and I feel almost completely normal. Personally just plain old L-tyrosine worked really good for me at 500mg 2-3 times a day. (But I never took it for more than 4 days in a row) Today, I took 1000mg, with 1000mg Vitamin C ( a co-factor needed somewhere in the dopamine cycle) and green tea on an empty stomach. Everywhere I read to take it daily but then other people here on reddit reported about tolerance build-up so this might speak for occasional use (only if needed, not daily). Yea it does that for a week or two until you get used to the supplement. Conversely, I wonder why NAC is so widely used compared to L-cysteine which also has good research behind it. Noting that you don’t want to use it when you’re already sleep deprived. I have the british supplements brand of both. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. Also if there is some way to help prevent them from getting worse. Many Tyrosine brands sell capsules of 500mg L-Tyrosine plus a few hundred percent DV B6. It did seem to help me focus longer and meet deadlines, but the mental effect was subtle and I was never sure if it was a placebo. I've also incorporated into before workout and seemed to help turn my mood from "ugh let's get through this" to "I will conquer these squats and ride my row machine to victory" I have found l-tyrosine to be very effective for me but result in a lot of irritability and sleep disruption. I've had this same problem with Noopept, L-Tyrosine, NAC, and L-Theanine. Supplementation of L-Tyrosine will lead to more dopamine and less serotonin, while supplementing either L-Tryptophan or 5-HTP will lead to more serotonin at the expense of dopamine. This includes fapping too because it releases loads of dopmaine like drugs like adderall so expect the same benefits from it. I'm very anxiety-prone, and this has been just about the only dopaminergic supplement that has decreased, rather than increased, my anxiety. Is this normal? Frustrated I carefully tried L-Tyrosine as it acts on entirely different neurotransmitters (Dopamine, Adrenaline, Noradrenaline). 500 to 1000 mg was always fine with me. 10/1 ratios for tyrosine/htp, to encourage the dopamine/serotonin cycle, typically 1000mg tyrosine in the am, 100mg 5htp 30 minutes before bed (with melatonin if I'm trying to move my cycle earlier) When you only view the bio-chemie aspect you need l-tyrosins to build l dopa in your brain, so l-tyrosin is an amino acid to Build dopamin, in this case you cant overdose it, because your Brain will regulate the Building of l-dopa, but you need to know that you cam overdose l-dopa and this will make the side effects that some may experience. org Jul 4, 2014 · L-Tyrosine is a precursor to norepinephrine, which increases energy, alertness, clarity of mind, motivation, etc. Dosages 1000mg l Tyrosine in the am and l tryptophan 1000mg pm A typical CILTEP Stack consists of: 1-2 Artichoke & 1-2 Coleus extract pills, 1-2 g of Tyrosine or L-Phenylalanine, 25-50 mg P5P, 1-2 g of Acetyl-L-Carnitine, & a Caffeine source. This study pretty much says no. 85 gram of chicken has 1000mg tyrosine. check out the links below Anyway- along with a slow taper I avoided a nasty withdrawal by taking Vitamins D (x3 above RDA), vit b, methyl folate, L tyrosine, l theanine, valerian root to help sleep, NAC, fish/omegas, magnesium, Q10, Milk thistle and you could add 5htp at the lower end of the taper. Not a place for discussion of illicit and illegal compounds. anyways Dopamine is created by amino acids in our brains, so L-tyrosine is supposed to boost the brains ability to produce natural dopamine. That being said I have never noticed a increased heartbeat from L-tyrosine. So depending on why your using it you can cycle a week on a week off to keep the suppression going or go daily without cycling and it’ll go, leaving you with the other benefits of supplementing L-tyrosine. No difference at all. So, either you'll be on sugar or you'll be lethargic. Tyrosine derives from phenylalanine. 13 votes, 21 comments. IMO, they both do different things. Metabolizes into phenylalanine and dopamine. DLPA gave me no energy or mood benefits. first time do you recommend anything or should i do anything before. Is this potentially a result of too much norepinephrine? I’m debating on if I should cycle tyrosine throughout the week. However, I have noticed some weird changes. 5g for a 200lb person and 7-10g for a 150lb person. Much appreciated thanks. Phenylalanine converts to L-tyrosine so you could still run into some of the same issues I would assume but if you’re still looking for something that works on dopamine this would be my next step if I went to cvs and got some 5htp and L-tyrosine and took them at the balanced percentage as describe online by a doctor. Thus, this edge you feel is likely due to the increased levels of dopamine. So I've just started making my own pre workout - 5g creatine, 7g of citrulline malate and some BCAAS. Though even for tyrosine i needed some time to start noticing effects, word of caution, becareful when tampering with your neurotransmitter balance, especially with dopamine. Additionally, tyrosine eventually upregulates your receptors so after a few weeks, it will stop giving you the desired effects anyway. Fasted or out of the AUC for a full profile amino acid. Because we can all suggest something but if it really does the job with no side effects. No Advertisements Posts & Comments Reported as: Advertisement. Similarly, L-tyrosine and L-tryptophan are effective only if there's a deficit in in their production, which can be addressed by adequate protein intake, usually. Basically, the synthesis pathways of both dopamine and serotonin catecholamines rely on an enzyme known as Aromatic Amino Acid Decarboxylase (AAAD). 5g empty stomach or 2g would have minimum effect and 500-1000mg would do zero. Probably a Chinese psy-op anyway) and it can elevate your avg dopamine levels. e. No selling / buying / trading posts No advertisements. All that is left of my severe anxiety is some very very slight lingering tension. I. I took 500mg in the morning on an empty stomach, and 250mg a few hours later. 3 or 4 times I've also added around . now i'd try l-theanine. L-Tyrosine does work. Thyroid hormone sensitises beta adrenergic receptors so can aggravate anxiety - so what you may find on reddit is that a lot of people who take tyrosine long term eventually end up with anxiety after taking it, but this hasn’t been studied. 75 to 1. From what I understand if you take l tryosine on a regular basis the enzyme that converts l tryosine to l-dopa then dopamine, is going to downregulate on its own anyways making that little dopamine boost disappear. I found DLPA to be much more helpful compared to l-tyrosine without any negative side effects. I definitely feel noticeably different on L-Tyrosine. I believe it is safe to take for a brief period of time and it’s used by alcoholics and drug addicts to improve willpower and reduce withdrawal symptoms. i also got saffron, l-tyrosine, phenylethylamine, zinc with c and b6 324K subscribers in the Supplements community. Unfortunately we can't help with this one. I know I need to be careful but I thought its pretty safe compared to ADHD meds or other hard drugs. All seemingly regardless of amount, stack, dietary considerations, etc. [37] 56% of the adminstered dose of NALT is excreted in 4 hours[37] and another study suggests that, overall, 35% of the total NALT So I checked the ingredients : vitamin B3, B12, Folic Acid, L-Carnitine,Green Tea, L-Theanine, L-Tyrosine, 5-htp and some plant extracts. I was already taking an iron supplement for years prior, since I donate blood regularly. As far as I know L-Tyrosine conversion to Dopamine is limited by various enzymes so there should be no crash (if L-Tyrosine plasma levels were even increased after such a dose). If you, for whatever reason, burn through catecholamines, do not absorb protein well, or otherwise end up with a tyrosine deficiency, then you might benefit from 500-1000mg/day of l-tyrosine. While I was influenced from L-Tyrosine I experienced: increased alertness and focus, subtle ego inflation on high dosages, and other irrelevant things. Maybe you don't eat enough protein? Maybe you need to see a doctor? Otherwise, L-Tyrosine supplementation doesn't do any of that. I spent the day relatively ok but around 7pm, had a massive crash/fatigue + headache that I clearly felt was related to supplementation. Well, you should go see a health professional about this one. A low grade throb that never went away. But people here are talking as if it is akin to drugs, which with 1000mg per day is kinda ridiculous. Especially being on anti depression medication. As an ADHDer l-tyrosine seems to help a little bit. Giving it sugar will hijack the dopamine release by at least 1500 times more than that of a non l-tyrosine users. 5g (my scales aren't super accurate) of l-tyrosine. IMO, tyrosine should be used no more than 1-2 times a week for periods of high stress or if youve pulled an all nighter (as tyrosine mitigates cognitive decline associated with sleep deprivation). A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any… i just bought mucuna extract 400mg cap its say (min. When you take Tyrosine with it, it becomes a reliable and sustainable stimulant that most people respond to. Tyrosine can be more easily metabolised in the gut and adrenal glands to tyramine, adrenaline and thyroid hormone. For someone who doesn't workout with an office job, 200g is more than enough to cover your Vyvanse. L-Tyrosine is an amino acid (don’t ask me what that means. Business as usual on RR. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any… N-Acetyl-L-Tyrosine appears to be able to contribute free L-Tyrosine in vivo after administration IV administration, but only able to increase L-Tyrosine concentrated 20% despite much larger increases in serum NALT. Adding more L-Tyrosine does NOT raise L-Dopa levels unless you are majorly deficient. I used to take the Now brand L-Tyrosine 500mg occasionally for 3-5 days in a row if I was having trouble with procrastination and lack of focus. Personally I would only use Tyrosine or Phenylalanine with theanine. In fact, I bookmarked it! NALT works better for me too, and it takes a fraction of the L-tyrosine dose. I prefer DLPA over L-Tyrosine since the effects of L-Tyrosine don’t last that long, while DLPA will give me a boost in executive function for several hours. There are a lot of posts about tyrosine and studies do not support any beneficial effects of tyrosine. But recently switched to the product sold by Advanced Orthomolecular Research. Jul 31, 2024 · Tyrosine is a precursor to thyroid, adrenocortical hormones and to dopamine. After about a week of discontinuing the L-Tyrosine, I had terrible anxiety, and a constant feeling of my throat was closing up, similar to what people say about hypothyroidism. Except, that is just part of it. ” I am a bot, and this action was performed automatically. maybe try 250 mg? I started taking L-Tyrosine shortly after starting a B-complex from life extension. However, there's some uncomfortable side-effects: I always get a terrible headache and also sweat more. the first few times were fine (good workout) but the last few times were too intense? Studies in humans showing most anti-stress promise for acute supplemental L-Tyrosine use a dosage range of 100–150 mg/kg of bodyweight which can be taken 60 minutes before exercise; this is a dosage range of 9–13. Not many know this but n-acetyl l-tyrosine has zero absorption. It doesn’t feel the same effects exactly though. A week or so ago I took L-Phenylalanine for the first time. 500mg. So here's a round-up: Since there's no dosing guidelines people just play around and experiment, and you get people taking 1-2g of tyrosine and agmatine, and even 2-3g of phenubit then complaining about previously unknown side effects. L-Tyrosine is a non-essential amino acid. that I need to last long hrs. In theory, there should be no reason to supplement but what if someone is soo depleted from dopamine that restoring levels could be achieved quicker by supplementing directly with L-dopa for a short amount of time to help it a long. If I take it with amphetamine, the amphetamine effects are always strongly potentiated, as well. You'll have an endless supply of dopamine. Rather than experimenting on yourself and going 300g protein with added multiple L-Tyrosine throughout the day, just go to your doctor so they can change the dose. Lions mane effects definitely became stronger after taking a break then starting again for the first week or so, particularly combined with l tyrosine and caffeine. 5g for a 200lb person and 7-10g for a 150lb person Also, L-tyrosine inhibits the synthesis of serotonin. Just posting as an FYI should anyone else have this side effect, it’s a common one but I didn’t realize it. I get that effect when I take high doses of Sudafed, which also increases norepinephrine. Those effects don't come from L-Tyrosine supplementation. Nothing major but nothing negligible either, hard to say exactly though. ADHD is really complex condition and the cause is still not clear to scientists, but its clear that ADHD medication like methylphenidate seems to be really effective. CILTEP has done WONDERS for giving me the mental clarity, energy, drive, endurance, moodlift, focus, work ethic, etc. Sensitivity to l-tyrosine varies a lot. supplementing 5-HTP alone would give rise to a situation in which there is a far greater concentration of 5-HTP than L-DOPA, causing it to dominate at the enzyme level. But that's my way of thinking. I expressed it being a null result because, for whatever reason, I did not experience any of its studied effects relevant to my person. Some of the symptoms of its deficiency include low body temperature, low blood-pressure and restless legs'. on days were I do exercise, but don't take L-Tyrosine, I'm slightly better and more present and alert, but still below baseline for most "neurotypicals". Pathway = L-Tyrosine -> L-Dopa -> Dopamine It enhances focus and attention, but it does come with a crash after. If you really want to know. 3nmol/L (baseline and similar to control values) to the range of 140-168nmol/L within 90 minutes, which remained within that concentration until measurements stopped at 150 minutes; a significant difference from placebo existed within 30 I have switched to a high protein diet that consists of more than enough important amino acids like L - Tyrosine . And the 2nd dose maybe an hour before dinner (again MUST be on an empty stomach for absorption). If you like Tyrosines effects on you, don't go replacing it with L-Dopa without researching the risks. 364K subscribers in the Nootropics community. It took a few weeks to realize it was from the L-tyrosine. Also mucuna 15% l-dopa extract gave me bad anxiety similar to tirosine. Decided to buy some 500mg L-Tyrosine pills for help with motivation and just that feeling of energy you have as a teenager… What others have been saying is correct, it is involved with dopamine production along with a rate limiting enzyme known as tyrosine hydroxylase, which converts l-tyrosine to dopamine using B6 as a substrate. HOWEVER, Tyrosine Hydroxylase is tightly rate limited. So the combo for me is 1 pill of l tyrosine 500mg and one latte around 100mg of caffeine this is work for me, maybe if instead of 500mg of l tyrosine I use 1000 mg the effects will be bigger, I still think 500 mg is a small dose but in my case is working. 335K subscribers in the Supplements community. -Tyrosine is much more low risk than taking L-Dopa due to it being behind some metabolization limits. Also, dopamine converts to norepinephrine and epinehrine when the enzyme Dopamine beta hydroxylase is activated. But it is a great option for people who are desperate and have no acces to medication! I was on Bacomind® and no amount of l-tyrosine or caffeine could penetrate the lethargy. Do I need to take L-Tyrosine daily to get the full effects or does it even have a cumulative effects similar to SSRIs (which only start working after 2-4 weeks daily use). You should be fine, L-tyrosine increases dopamine which increases norepinephrine which could be responsible for a increased heart beat or anxiety from it. But that may have to do with the severity of my ADHD. My psychiatrist recommended L-tyrosine and said it worked best when taken on an empty stomach, at least 30 minutes before eating. ) L-tyrosine, L-theanine and 5 HTP also helped me before I got acces to medication! I wouldn't call it holistic, it has more risks than traditional medication with less effective ADHD management (especially over time the effects can vary). I have used l-tyrosine for a couple of different effects: In adjunct with 5-htp, to move my sleep cycle. Masturbation in moderation is generally healthy, but excessive porn use can have serious adverse effects. ashwagandha didnt really agree with me, I became quite apathetic and grumpy. 20% l-dopa) and im predisposed to sz but am not. Never felt anything even on an empty stomach at 1000mg (no caffeine all week). L-Tyrosine is a precursor to L-Dopa, which is a precursor to dopamine. L-Tyrosine is one of the safer supplements out there (You may be confusing it with Tyramine, which can increase heart rate and anxiety when paired with MAOIs. (Also, serotonin synthesis requires B6, B3 and magnesium. No selling/trading posts between users. Been taking them for about a week now and noticed worse mood, anger, irritability, depression , lethargy brain fog and terrible anxiety, if someone can help me out please. Please contact the moderators of this subreddit if you have any questions or concerns. I've noticed it improves my mood and alertness when I'm sleep deprived and it may have slightly improved my ability to concentrate in school (I have ADD). You may indeed have low dopamine - but I don't think trying to support dopamine by cramming in L-Tyrosine is the way. No other full profile aminos for at least an hour afterwards. i found adding 500 mg of l-glutamine helped, this was 10 years ago. I use 500mg and I clearly notice an emotional rise in my day to day. You should raise the nightly L-Tryptophan dosage to 1,000mg. Discussion of nootropics and cognitive enhancers. Tyrosine competes with the other five Large Neutral Amino Acids for transport across the blood-brain barrier and into cells. I’m currently experimenting with lower dosing in the neighborhood of 100 - 150 mg, and find that I am able to reduce the negative effects while experiencing heightened focus and motivation. If you have a cancerous melanocyte - which can happen despite the presence of melanin due to many many factors - and you start taking a supplement that feeds these cells which are now cancerous (this part is what the cited papers are about), you're gonna have a bad time. Tyrosine is difficult to take appropriately. I also have little to no effect with l-tyrosine, if anything I’ve actually had negative effects/ side effects. I am much more impatient, I am much more sensitive to sounds, and I get angrier easier. Dopa Mancuna can cause some bad neurological problems I would not use it often. L-Tyrosine is not truly a drug in a traditional sense. Helps with burnout caused by overreaching. After that I’ve found the appetite suppression stops. I also was always anxious after l-tyrosine, taking it alone in standard doses and combining it with caffeine for a week resulted in so terrible mood that i felt like i had a depression and i never touched it again. The L-theanine takes the edge off the caffeine a bit without taking away the clarity, and the L-tyrosine helps avoid afternoon stimulant crash (works great for this actually) and improves my word recall. L-tyrosine and NALT continue to give me lightly amphetamine-esque effects pretty much every time I take them. The headache I got taking L-tyrosine was terrible. 11 votes, 21 comments. But with l-phenylalanine I pretty much never have side effects but have great benefits. Before you run off and buy a bunch of supplements containing L-DOPA, you should know that it's not going to do what you think it's going to do. As far as I can tell, they don't compete or cause negative side effects. 4. I just told my little sister (who has ADD and had no luck with Stims) she took 500 mg of L-Tyrosine with a B complex 2x/day. However at rest and properly fed it will have no significant effect. . I did a lot of research about these supplements and I suggest you do the same. The fact that you even think you had a fraction of the effect from "Limitless" tells me that you are delusional. So it's important to take 250mg - 2g of L-tryptophan as well (at least four hours apart from L-tyrosine) or else the lack of serotonin synthesis can lead to issues like feeling irritated or anxious. I take 1,000 mg (two 500 mg capsules) in the morning with my Vyvanse and vitamin D on an empty stomach (at least 30 minutes before I eat breakfast). NALT seems to feel a little better and smoother for me, but the effects of both seem pretty similar. Though the use of this amino acid can be considered like a drug, in some sense. It's more effective to try and target the production of the enzyme instead, since L-tyrosine is pretty abundant anyway. I remember you talking about it 4 years ago. The same has always been the case for me with l-tyrosine as well, the l-tyrosine had a much more profound effect on my depression and low mood but then within a few days to a week it would be gone even at 1. L-DOPA bypasses a rate-limiting step in dopamine synthesis, which produces a more forceful increase in dopamine concentrations in the brain that can't be achieved by L-Tyrosine synthesis. More tyrosine is usuful when you are under stress, then it can provide some benefit. If you eat protein at a normal quantity, you get plenty of dietary L-Tyrosine. But I'm REALLY curious why some feel better from NALT and others, L-tyrosine. When L-Tyrosine effects wear off I started experiencing for 8+ hours: better focus, elevated mood, easily to talk and like my ADD doesn’t existed anymore. Very occasionally (1x per week maximum) use 500mg to 1,000mg of L-Tyrosine – which is a precursor to dopamine. So complementing that regimen with 500-1000 mg of L-Tyrosine, just may be too much. true. Yes I understand the difference and understand that Tyrosine through L-Dopa can theoretically lower serotonin levels. 3oz (85g) of lean chicken breast has about 1000mg of L-Tyrosine. No obvious stimulation affect. 5 g for a 200 lb person and 7–10 g for a 150 lb person. You also MUST take L-Tyrosine with a Vitamin B Complex on an empty stomach for this to work. Instead, additional L-Tyrosine is more likely to go down the 4. This might be the coffee and not L-Tyrosine. This version appears much fresher and the lethargy effect isn't 'in your bones' but rather 'in your face' and it can be mitigated by caffeine. More tyrosine doesn't really result in more dopamine except for an initial increase. First dose as soon as she awakens. Hey, planning to add L-Tyrosine to the below stack, Please suggest, any reactions or side effects which this can cause ? Zinc Magnesium glycinate L citruline and Citruline malate Gingko Biloba - 120mg Vit E Vit K2 mk27 Vit D3 and Calcium B- Complex Beta Alanine Taurine Plant protein Maca root (occasionally) i found a can get a little intense with 2 grams + 3 coffees and no food. It's worked great for me. On the first or second day of L-Tyrosine, I had chest pain so bad I thought I was having a heart attack. If you are not synthesising enough L-Dopa from dietary L-Tyrosine, dumping in more is not going to change that - and that is likely the case, and I doubt it's to do with nutritional deficiency of L-Tyrosine. Time will tell, I have no real hope. I take it in the morning, an hour before eating, with Vitamins C and B6 (these will help L-Phenylalanine's eventual conversion to dopamine and norepinephrine). I'm very sure I have ADHD, depression especially SAD and have taken Tyrosine low doses on and off for 2 years, so I didn't expect much from it. 500mg to a gram will give you good effects. 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