25g/L of poloxamer 188 for 4 days. 1 * Ethylene oxide 75-21-8 <0. 4 INCI name. 1. Identification Product identifier Kolliphor® P 407 Chemical name: Oxirane, methyl-, polymer with oxirane CAS Number: 9003-11-6 Pluracare® F 127 NF Prill is a copolymer of ethylene oxide and propylene oxide and has general functionality of surfactants, emulsifiers, solubilizers and stabilizers in preparations where the quality of poloxamer may be required. The elastic and viscous moduli of aqueous Poloxamer 407 Aug 1, 2017 · The impact of poloxamer 407 concentration on gel formation was evaluated and it was confirmed that increasing poloxamer 407 concentration impacted on T sol-gel, maximum recorded storage modulus, and viscosity with lower amounts of the purified poloxamer 407 needed to reach comparable levels to the unpurified, compendial poloxamer 407. ) for Poloxamer 407. Properties We would like to show you a description here but the site won’t allow us. BASF's portfolio of solvents and co-solvents are suitable for a wide range of applications and processing methodologies. media with 0. Apr 4, 2022 · Four different hydrophilic polymers: poloxamer 407 (Kolliphor ® P407, BASF, Germany), macrogol 6000 (Polyglykol 6000 S, Clariant Export AG, Switzerland), povidone (Kollidon ® 30, BASF, Germany), and copovidone (Kollidon ® VA 64, BASF, Germany), were used as carriers. Ph. Croscarmellose sodium (CCS, Ac-Di-Sol) was received from FMC Biopolymer, Philadelphia, PA. Poloxamer 407-based hydrogels exhibit an interesting reversible thermal characteristic. Apr 23, 2014 · Poloxamer 407. Feb 7, 2017 · Poloxamer 407 (P407) and 188 (P188) were obtained from BASF Co. ar. Mar 13, 2008 · Poloxamer 188 (PXM-188) and Poloxamer 407 (PXM-407) are among the most commonly used PXMs. have agreed to collaborate in the development of a higher purity poloxamer 188. reported that aqueous solutions of poloxamer 188 (Pluronic F-68) and poloxamer 407 Microprilled Poloxamer 407 Solubilizer for the pharmaceutical Industry. In particular, thermosensitive gels based on poloxamer 407 (P407) have great potential for periodontal disease treatment, thanks to their ability to be liquid at room temperature and become viscous gels at body temperature. Cubic nanoparticles were prepared through fragmentation of the GMO/poloxamer 407 bulk cubic gel . Coprocessed excipients are combination, all-in-one solutions. GMO and poloxamer 407 in different weight ratios were first melted at 60°C in a hot water bath, after which simvastatin was added and stirred continuously until total dissolution. 3 Details of the supplier of the safety data sheet Company: MedChemExpress USA Tel: 609-228-6898 Fax: 609-228-5909 ポロキサマー(Poloxamer)は、ポリオキシプロピレン鎖(POP)と、それを挟む2個のポリオキシエチレン鎖(POE)からなるブロック共重合体である。 全体としては親水性が高いが、POP部はPOE部より親油性が高いため両親媒性を示し、界面活性剤として用い The Poloxamer 407 grades are poloxamers from the extensive line of Pluronic ® block copolymers. Poloxamer 407 is a water-soluble, non-ionic surfactant with low toxicity and good solubilizing capacity. Hence, there exists a literature gap on the effectiveness of P188 in terms of neuroprotection and its association with various CNS disorders in in vitro and in vivo models. BASF poloxamer 407 Poloxamer 407, supplied by BASF, used in various techniques. INCI: Poloxamer 407. , 2008; Takeo et al. 2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Synthesis of substances 1. As the temperature increases, the copolymer chains of poloxamer 407 aggregate into a micellar structure. See full list on pharma. Polyethylenglycol 400 (PEG400), emodin, and phosphoric acid were purchased from Sigma-Aldrich (St. 2 Physicochemical properties. Japan), and cholesterol (BDH, USA). 0 g/kg day-1) produced slight transient diarrhea in dogs. With increasing Jul 1, 2020 · Carvedilol (CAR), a β-adrenoceptor and α1-receptor blocker, has pH-dependent solubility, which greatly limits its oral bioavailability. PLURACARE® F 127 NF is suggested for use in skin and oral care products. Poloxamer 407 9003-11-6 100 * Propylene oxide 75-56-9 <0. The word “hydrogel”, according to Lee, Kwon and Park is due to an article published in 1894, but the first crosslinked network material that appeared in literature and that has been described by its typical hydrogel properties, was a polyhydroxyethylmethacrylate (HEMA) hydrogel developed much later, in 1960, by O. A copolymer of ethylene oxide and propylene oxide and has general functionality of surfactants, emulsifiers, solubilizers and stabilizers in preparations where the quality of poloxamer may be required. Kolliphor® P 407 is used primarily as thickening agent and gel former, as well as co-emulsifier and consistency enhancer in creams and liquid emulsions. 04. Fig. GA was purchased from 2A PharmaChem (Lisle, IL). Introduction. BASF is a large multinational chemical company that produces a variety of chemicals and polymers for industrial and pharmaceutical use. , USP/NF, Poloxamer 407; JPE: Polyoxyethylene (196) polyoxypropylene (67) glycol Gel formers Kolliphor® P 407 Geismar Enhances viscosity. Nov 11, 2006 · Poloxamer 407 copolymer (ethylene oxide and propylene oxide blocks) shows thermoreversible properties, which is of the utmost interest in optimising drug formulation (fluid state at room temperature facilitating administration and gel state above sol-gel transition temperature at body temperature promoting prolonged release of pharmacological agents). As the concentration of poloxamer in the gel increases, the amount of drug permeated from the formulation decreases as can be seen from Figure 10. 8b9b3a126845a7ad. Item Name: Kolliphor P 407 (Poloxamer 407) Make: BASF Minimum Pack: 90 Kgs Drum. Poloxamer 407 alters the level of heparin releasable and intracellular lipoprotein lipase, as well. It is freely soluble in water (opalescent solution) and ethanol; insoluble in diethyl ether, paraffin and fatty oils. , USP / NF: Poloxamer 338 18 / 80 Kolliphor® P 188 micro Lµtrol® MICRO 68 Ph. 5 wt. Feb 10, 2012 · Poloxamer 407 was obtained as a gift from BASF (Tarrytown, NY), TPGS was purchased from Sigma-Aldrich (St Louis, MO). Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol (PEG). , USP / NF: Poloxamer 237 25 Kolliphor® P 338 Lutrol® F 108 Ph. The impurities of commercial grade Poloxamer 188, as an example, include low-molecular-weight substances (aldehydes and both formic and acetic acids), as well as 1,4-dioxane and resid- Poloxamer 407 is widely used because it can form hydrogels at lower block copolymer concentrations in water, around 20% w / w. 54 ± 0. Isopropyl myristate (98%) and olive oil (pharmaceutical grade Dec 10, 2019 · 1. Mar 1, 2014 · In the repair + P407 group, 10 μL of the gel formed Poloxamer 407 (BASF, Nienburg/Weser, Germany) with a particle size of 10λ and was injected between the tendon and the supraspinatus footprint in the bone before tightening the suture (Figure 1 C). Get Dental Implant Screw at lowest price | ID: 24680909291 Oct 1, 2023 · Poloxamer 407 (P407) and poloxamer 188 (P188) are among the most commonly used poloxamers in ocular drug delivery. Pluronic® F-127 is usually dissolved in water or DMSO with gentle heating. efd010750da3c5d8. Kollicoat® coating polymers are suitable for a variety of oral formulation challenges. Pluracare® F127 NF Prill FLEX is a block co-polymer with an average molecular weight consists of propylene oxide and ethylene oxide. Moreover, Kolliphor ® P 407 is suitable for the formulation of active substances that show reduced solubility as well as chemical stability as a result of neutralization of gel formulations. Thermogelling amphiphilic block copolymers have been widely investigated in the development of pharmaceutical drug carriers. 05 wt. It is made up of two blocks of hydrophilic polyethylene glycol on either side of a central hydrophobic polypropylene glycol block. May 17, 2023 · Poloxamer 407 was procured from BASF (Germany), Brij-35 (Junsei Chemicals Co. actual graph represents the positive relationship between the dependent and the independent variables, and b residual vs. 15 min), which is expected since poloxamer 407 has a higher molecular weight than poloxamer 188. This ingredient possesses solubilizing and stabilizing properties. They contain an appropriate quantity of the antioxidant BHT. The coexistence of hydrophilic and hydrophobic segments endows poloxamers with a systematic transformation of physical properties with the temperature [13,14]. Tweet Jun 5, 2018 · This review paper aims to explore the available literature surrounding the use and mode of action of surfactants in wound healing, in particular Poloxamer 188 (Pluronic F‐68) and Poloxamer 407 (Pluronic F‐127), and also uncover the potential mechanisms behind the enhancement of wound healing and comparison to other surfactants used in wound B Kolliphor® P 407 Poloxamer 407 Gelling agent 18 C Deionized Water Solvent 42 D Kollicream® 3 C Cocoyl Caprylocaprate Emollient 10 ®Kolliphor P 407 helps emulsify the Kollicream® 3 C in this formulation, resulting in a translucent white gel with a cream-like structure visible underneath the microscope. Đây là một loại chất hoạt động bề mặt không ion polyme mới. 1 * 1,4-Dioxane 123-91-1 <0. %, BASF, Ludwigshafen, Germany), and of calcium chloride (0. 67 min) is slightly shorter than that of the poloxamer 188 (11. To determine if Poloxamer 407 (poloxamer, Pluronic F-127; BASF Wyandotte Corp. PLURACARE® F127 by BASF is a non-ionic surfactant. Functioning as a dispersant, gelling agent, lubricant, plasticizer, solubilizer, stabilizer, and wetting agent, it finds application in drug delivery and care solutions. 1–3 When dissolved in aqueous solution, P407 forms a hydrogel useful for a range of biomedical applications. These products were developed t. 2. BASF intraosseous injective thermosensitive simvastatin hydrogel poloxamer 407 Intraosseous Injective Thermosensitive Simvastatin Hydrogel Poloxamer 407, supplied by BASF, used in various techniques. ZERO BIAS - scores, article Poloxamer 407 is a polyoxyethylene polymer and hydrophilic non-ionic surfactant. (microprilled Poloxamer 188) and Kolliphor® P 407 micro (microprilled Poloxamer 407) were microprilled to an average particle size of approximately 50 µm. Specification and properties. : 9003-11-6 1. CAS Number: 9003-11-6. Poloxamer 407 . ZERO BIAS - scores, article reviews, protocol conditions and more Brand: Kolliphor Chemical Name: Poloxamer 407. Oct 1, 2000 · Poloxamer gels also satisfy the major characteristics of an optimal dressing material for early management of skin burns 12. Lim, with the aim of using it in permanent For this investigation, poloxamer 188 (Lutrol® F68) and poloxamer 407 (Lutrol® F127), both BASF SE, Ludwigshafen, Germany were used. 3 Details of the supplier of the safety data sheet Company : Sigma-Aldrich Inc. The suture was then tightened, securing the tendon down to the bone. That is, they are liquid at room temperature, but they assume a gel form Jul 28, 2009 · Preparation of GMO/Poloxamer 407 Cubic Nanoparticles. Micelles of Poloxamer 407 will have extended, well-hydrated outer shells of PEO, which rapidly leads to a closely-packed organization of the micelles above the cmt. This triblock copolymer is composed of a hydrophobic residue of polyoxypropylene (POP) flanked by two hydrophilic units of polyoxyethylene (POE). It can be applied as liquid at room temperature and forms a hydrogel by reverse thermal gelation upon contact with the warmer human body . ®The dynamic viscosity of Kolliphor P 407 Geismar gels may be affected by the addition of electrolytes, moisturizers, alcohols and surfactants. (Ludwigshafen, Germany). To make a poloxamer 188 solution, add room temperature water to a beaker with a magnetic stirrer on a stirrer plate. 5% level, but no change in survival. Kolliphor® P 407 is supplied as white to slightly yellowish, coarse-grained powder with a waxy consistency. Chemical Name: Poloxamer 407. Feb 25, 2020 · Poloxamer 188 (P188 micro) and Poloxamer 407 (P407 micro) were received from BASF (Ludwigshafen, Germany). ZERO BIAS - scores, article reviews, protocol conditions and more 10% poloxamer 407 15% poloxamer 407 20% poloxamer 407 Fig. %) and xanthorrhizol (0. Gelation results from hydrophobic interactions between Poloxamer 407 copolymer chains. , USP / NF, JP: Poloxamer 188 25 Kolliphor® P 407 micro Lµtrol® MICRO 127 Ph. Originally P407 was developed as an emulsifying agent in cosmetic and The word poloxamer was coined by BASF inventor, Wang et al. , Poloxamer USP/NF Poloxamer for Pharmaceutical Use March 2020 | WF-No. Công dụng: Thích hợp để hòa tan các hợp chất hoạt tính và hương INCI Name: Poloxamer 407 Functions : Bulking Agent, Co-Emulsifier, Gel Former, Solubilizer, Surfactant, Surfactant (Nonionic), Thickener, Viscosity Modifier Labeling Claims : Clean at Sephora, Ulta Beauty's Conscious Beauty Kolliphor® P 407 Geismar Enhances viscosity. 1 Product: Kolliphor® P 407 (ID no. They are widely used as a thickening agent and gel binder. Thanks to its A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics Gilles Dumortier,1,3 Jean Louis Grossiord,2 Florence Agnely,2 and Jean Claude Chaumeil1 Received March 23, 2006; accepted June 27, 2006; published online November 11, 2006 Abstract. Establish Pluronicpluronic ® F-127, also known as poloxamer 407, is a non-toxic and nonionic copolymer. Benefits. 2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, manufacture of substances. Kolliphor ® P 237 Lutrol F 87 Ph. Because of its surfactant nature, the poloxamer also BASF poloxamer 407 polox Poloxamer 407 Polox, supplied by BASF, used in various techniques. All other reagents and buffer solutions were of analytical grade. molecular weight of the PPO are indicated in the name of the poloxamer. 5 CAS-No. , 2002). It consists of a central hydrophobic block of polypropylene glycol that is flanked on each side by polyethylene glycol blocks, both hydrophilic in nature. %) as additives in an aqueous solution form. ZERO BIAS - scores, article reviews, protocol conditions and more BASF's portfolio of solvents and co-solvents are suitable for a wide range of applications and processing methodologies. Figure 3 demonstrate Pluronicpluronic ® F-127, also known as poloxamer 407, is a non-toxic and nonionic copolymer. or. Ltd. USA). Jul 4, 2022 · 1 Introduction. , 2006; Chiappetta and Sosnik, 2007; Nanjawade et In order to determine which information is relevant for me, BASF may collect, analyze and share between themselves my personal information, information about my professional needs and interests (including those derived from my interactions with these marketing messages) and from my overall customer relationship with BASF. 1. drug delivery, bioavailability, stability, solubility, etc. DAWF-2019-0813 03_190801e-00/Page 1 of 6 Kolliphor® P 407 Geismar, a poloxamer 407, serves as a versatile pharmaceutical-grade ingredient. 3050 SPRUCE ST ST. Jul 1, 2020 · The most universally consumed grades of poloxamers are Poloxamer 188 and 407 [12]. Jan 18, 2018 · Poloxamer 407 is widely used because it can form hydrogels at lower block copolymer concentrations in water, ar ound 20% w / w . Poloxamer 407 (P407) is a polydisperse mixture of triblock copolymerization with a molecular weight of 12. 4. Data Sheet (Inglês) D'lite - Sustainability Data (Inglês) Pluracare® F 127 NF Prill é um copolímero de Kolliphor® P 188 BIO is supplied as white to slightly yellowish, coarse grained powder with a waxy consistency. Aug 1, 2008 · Poloxamer 338 (at 5. Thermoreversible gelling effect. Data Sheet (Inglés) D'lite - Sustainability Data (Inglés) Pluracare® F 127 NF prill es un copolímero de BASF nf grade lutrol f127 poloxamer 407 Nf Grade Lutrol F127 Poloxamer 407, supplied by BASF, used in various techniques. For certain active substances such as nifedipine, naproxen and fenticonazole as well as for essential Poloxamer 407 is a hydrophilic non-ionic surfactant of the more general class of copolymers known as poloxamers. 86 ± 0. This product has an average molecular weight of 12,600, a viscosity of 3,100 cP, and a pour/melt point of 56°C. Graph shows viable cells at Day 4 4. Nov 11, 2006 · Abstract Poloxamer 407 copolymer (ethylene oxide and propylene oxide blocks) shows thermoreversible properties, which is of the utmost interest in optimising drug formulation (fluid state at room temperature facilitating administration and gel state above sol–gel transition temperature at body temperature promoting prolonged release of pharmacological agents). Poloxamer 407 is a polyoxyethylene polymer and a hydrophilic non-ionic surfactant. Poloxamer 188 was developed for oral and topical pharmaceutical applications Cell culture process intensification Collaborative investigation Cell & Gene Therapy applications Kolliphor®P188 Bio launch Variability in cell culture reported to BASF Cell culture manufacturing applications 1960 1980 2000 2012 2014 2016 2020 INCI: Poloxamer 407. Aug 30, 2017 · The impact of poloxamer 407 concentration on gel formation was evaluated and it was confirmed that increasing poloxamer 407 concentration impacted on T sol-gel, maximum recorded storage modulus, and viscosity with lower amounts of the purified poloxamer 407 needed to reach comparable levels to the unpurified, compendial poloxamer 407. Feb 2, 2018 · For 40% poloxamer gels, the amount of drug permeated from the extruded gel was 2. It is a pale yellow oily liquid that is clear at temperatures above 26 °C. 2018 1. Poloxamer 407. Công dụng: Thích hợp để hòa tan các hợp chất hoạt tính và hương Nov 13, 2023 · Poloxamer 407 is part of the Pluronic family of polymers, which are proprietary products of BASF Corporation. 5% in diet given to rats in a 2-year feeding study produced diarrhea at 5% and 7. Both products contain BHT. 1 Chemical nature. Sodium lauryl sulfate (SLS, BASF, Ludwigshafen am Rhein, Germany) was used to prepare dissolution medium. rking as solubilizing agents. Poloxamers are another type of thermo–sensitive hydrogels with an ABA–type triblock structure (Fig. Poloxamer can save cells from necrosis by intercalating to the cell membrane, sealing the membrane rupture, and reducing the depolarizing, nonchannel-mediated ion flux. , Parsippany, NJ) is as effective as Interceed(TC7) (Ethicon, a Johnson and Johnson company, Sommerville, NJ) in preventing postoperative adhesion formation using the rat uterine horn model and to determine if the presence of blood or lactated Ringer’s solution affects the effectiveness of Poloxamer 407. Specifications. Kolliphor EL is a non-ionic solubilizer and emulsifier made by reacting castor oil with ethylene oxide in a molar ratio of 1:35. , USP/NF, Poloxamer 407; JPE: Polyoxyethylene (196) polyoxylpropylene (67) glycol Oct 12, 2015 · BASF Corporation (BASF) and Mast Therapeutics, Inc. Ritonavir (RTV) was received from Wuhan Beier Biopharm Ltd. BASF offers a broad portfolio of brand families that are suitable for oral, topical, parenteral, and biologic applications. 402, 403, and 407, Poloxamer 105 Benzoate, and Poloxamer 182 Dibenzoate as Used in Cosmetics1 Poloxamers are polyoxyethlyene, polyoxypropylene block poly-mers. Eur. basf. Apr 26, 2023 · The formulations with 0% poloxamer 407 can be seen at the lower end of the graph, while the formulations with some amount of poloxamer 407 are at the top end (Table VI). Kolliphor® P 338 is supplied as white or almost white, coarse grained powder with a waxy consistency. Dec 10, 2011 · The material used in this study is a physical mixture that is mainly composed of poloxamer 407 (23 wt. For example, P 188 succeeding the word Kolliphor® indicates a poloxamer with ca. It is soluble in water, ethanol (95%) and isopropanol. , 2015). Poloxamer 407 copolymer (ethylene oxide and propylene oxide blocks) shows thermorever- Apr 1, 1993 · Objectives. 4) (Kabanov et al. In the presence of calcium, the packed poloxamer 407 micelles allow the Ca 2+ to diffuse, and a network gradually forms. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern. May 25, 2022 · Both, the investigated poloxamer 407 (a poloxamer with larger EO and PO units compared to P188, see Table 2) and P188 contained a specific amount of the antioxidant BHT (butylated hydroxytoluene). ZERO BIAS - scores, article reviews, protocol conditions and more Article Investigating the tunability of Poloxamer 407 and Poloxamer 338 Gels Request Download Webinar Irritancy & Allergenicity of Topical Ingredients Watch on-demand now Apr 9, 2023 · Poloxamer 407 là chất hoạt động bề mặt không ion ưa nước thuộc một nhóm lớn được gọi là Poloxamers. For enquiries please contact us. Pluracare® F127 NF Prill FLEX has guaranteed low 1,4-dioxane levels to support formulators in meeting new regulatory limits. 6 kDa. , 2017). Poloxamer 407 (P407), also referred to as Pluronic F-127, is a tri-block copolymer, comprised of polyethylene oxide (PEO, ~70%) and polypropylene oxide (PPO, ~30%). a Ingredien. 80% m/m PEO (P 188; 8x10= 80%) and approximately average molecular weight of PPO of 1800 (P 188; 18x100= 1800) 2. For certain active substances such as nifedipine, naproxen and fenticonazole as well as for essential oils in pharmaceutical formulations Kolliphor® P 407 is also used as a polymeric solubilizer. g. Ethanol 96% (v/v) was used as a solvent for SDs preparation by solvent CAS: 9003-11-6 Synonyms: Polyethylene-Polypropylene Glycol Pluronic® F-127 is a nonionic detergent useful for solubilizing hydrophobic dye molecules such as cell-permeable AM esters of Fura-2, Fluo-3, Indo-1, or Rhod-2 calcium indicators to facilitate cell loading. Indeed, poloxamer-407 gels with entrapped bacteriostatic or bacteriocidal agents have been used as an artificial skin in the treatment of third-degree burns 13. The sample was used as received. Millipore poloxamer 407 p407 Poloxamer 407 P407, supplied by Millipore, used in various techniques. predicted graph represents the Jan 18, 2018 · Poloxamer 407 is widely used because it can form hydrogels at lower block copolymer concentrations in water, around 20% w/w. Sep 3, 2004 · The retention time of poloxamer 407 (10. Functions: Dispersant, Emulsifier, Gelling Agent, Lubricant, Plasticizer, Solubilizer, Wetting Video Formulating Poloxamer Gels BASF expert Amy Ethier explains how one can achieve the unique sensory properties of this increasingly popular pharmaceutical dosage form using both hot and cold process methods. 2: Complex dynamic viscosity of aqueous Kolliphor® P 407 Geismar-gels as a function of temperature. Poloxamer 407 European Pharmacopoeia (EP) Reference Standard; CAS Number: 9003-11-6; Synonyms: Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); find -P2164030 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich Poloxamer 407; Poloxamer 407 has been widely used as a thickening agent and gel binder. of Poloxamer 407 Hydrogels with Casein Louise Lacalendola Tundisi1,2 & Rong Yang1 & Luiz Phellipe Pozzuto Borelli4 & Thais Alves3 & Manisha Mehta1 & Marco Vinícius Chaud3 & Priscila Gava Mazzola4 & Daniel S. Poloxamer 407 was developed and is marketed by BASF under the trade name Pluronic F127. 30555080/SDS_GEN_00/EN) Date of print 25. In cosmetic and personal products, poloxamer 407 is used as an emulsifier and solubilizer. 5% levels, a small decrease in growth at the 7. css"> <link rel="stylesheet" href="wxp-core Item Name: Kolliphor P 407 (Poloxamer 407) Make: BASF Minimum Pack: 90 Kgs Drum. Bioz Stars score: 86/100, based on 1 PubMed citations. , 2006, Fakhari et al. com Technical Information Kolliphor® P 338 Geismar Poloxamer Ph. 27 μg/cm 2. (Wuhan, China). The skin is the largest and most extensive organ in the human body. ZERO BIAS - scores, article reviews, protocol conditions and more Understanding scores. It is used as an emulsifier, solubilizer, dispersing and wetting agent in the preparation of solid dispersions, and for the enhancement of the bioavailability of Introduction BASF’s Kolliphor P grade poloxamers are white, coarse- grained powders with a waxy consistency. It can be used as a thickening agent and gel former former or a co-emulsifier and viscosity enhancer in creams and liquid emulsions. 6 a Predicted vs. BASF lutrol f68 f127 poloxamer 188 407 polyethyl oxide Lutrol F68 F127 Poloxamer 188 407 Polyethyl Oxide, supplied by BASF, used in various techniques. Product name : Poloxamer 407 (F127) Catalog No. “Cold water“ preparation Pre-cooled water of 5 °C was weighed into a Request your sample of Pluronic® F127 Prill by BASF Personal Care today at Ross Organic an Azelis company. 31 μg/cm 2 and from the control gel was 1. Product name : Poloxamer 407 Product Number : 16758 Brand : Sigma CAS-No. Poloxamer 407|Poloxamer 407. It can also be used as a thickener, gelling agent, co-emulsifier and bodying agent in toothpastes, mouthwashes, creams and liquid emulsions. BASF Latin America; INCI Name: Poloxamer 407; Documentos. P407 is highly soluble in water and form transparent gel, so does not hamper normal vision. Product Properties and fields of Jan 21, 2020 · Because surfactant mixtures can have improved properties, it was hypothesized in this work that introduction of poloxamer 407 to aqueous solutions of polysorbates (polysorbate 60, polysorbate 80 and polysorbate 85) might improve their surface properties. PLURACARE® F 127 NF PRILL by BASF is a non-ionic surfactant and solubilizer. Methods For the investigation, solutions containing 10 and 20 % (w/w) poloxamer 188 and 10 % (w/w) poloxamer 407 in water were prepared. 4. Handling/Processing instructions P 188 Solution in Water Poloxamer 188 is soluble in water. Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. It is a tri-block co-polymer of propylene oxide and ethylene oxide. Date / Revised: 24. Technical properties Structural formula Poloxamer 407 interferes with catalytic activity of 3-OH-3 methylglutaryl Coenzyme A reductase, which represents the key-step of cholesterol biosynthesis. Dicetyl phosphate (DCP) was procured from (Ambeed Inc. <link rel="stylesheet" href="grid-angular. Search for pharma excipients offered by BASF and find excipient solutions (e. Kohane1 Received: 3 November 2020/Accepted: 15 February 2021 BASF's portfolio of solvents and co-solvents are suitable for a wide range of applications and processing methodologies. Acetonitrile, ethanol and methanol were purchased from Honeywell Burdick & Jackson (Muskegon, MI, USA). Dosage Form: Creams, Dispersions, Emulsions, Foams, Gels, Soft Gels. The elastic and viscous moduli of aqueous Poloxamer BASF Safety data sheet according to UN GHS 4th rev. Poloxamer 407 là một chất đồng trùng hợp bao gồm một khối kỵ nước ở trung tâm là Polypropylene glycol và được bao bọc bởi hai khối Polyethylene glycol ưa nước. Eur. Mar 3, 2022 · Noticeably, most poloxamers-based studies used other variants of poloxamers in the family, such as Poloxamer 407. B Kolliphor® P 407 Poloxamer 407 Gelling agent 18 C Deionized Water Solvent 42 D Kollicream® 3 C Cocoyl Caprylocaprate Emollient 10 ®Kolliphor P 407 helps emulsify the Kollicream® 3 C in this formulation, resulting in a translucent white gel with a cream-like structure visible underneath the microscope. This hypothesis helps explain the gradual erosion in the presence Pluracare® F 127 Prill is a block co-polymer that functions as a thickener, gelling agent, co-emulsifier, and bodying agent in toothpastes, mouthwashes, creams, and liquid emulsions. For further information on the microprilled Kolliphor® grades please refer to the individual Technical Information sheets. It is insoluble in ether, paraffin and fatty oils. Poloxamer 407 (Pluronic® F127, PEO 9 9–PPO 67 –PEO 9 9) is widely employed for drug delivery because it is reported to be non–toxic and can form gels at 25 ° C at a concentration of 20 wt% (Dumortier et al. BASF's portfolio of solvents and co-solvents are suitable for a wide range of applications and processing methodologies. Pharmaceutical evaluation Poloxamer 407 (P407) is an uncharged synthetic amphiphilic triblock copolymer composed of a hydrophobic polypropylene oxide block flanked by two lateral hydrophilic polyethylene oxide blocks. Mar 19, 2019 · Poloxamer ® 188, Poloxamer ® 407 (BASF, Ludwigshafen am Rhein, Germany), and polyvinylpyrrolidone K29/32 (PVP, Ashland, Covington, KY, USA) were used as excipients. 2 Structural formula. Labeling Claims: Aflatoxin-free, Allergen-free, BSE-free, Contamination-free, Dioxin-free, Gluten-free, Latex-free Nov 11, 2016 · As the temperature increases, the poloxamer 407 micelles form a close three-dimensional hydrophilic polymer networks, leading to a sol-to-gel phase transition. Sep 22, 2023 · Poloxamer 407. Microprilled Poloxamer / Kolliphor P407 micro) to address your drug development and formulation challenges (e. The necessary Poloxamer 407 dose to produce a hyperlipidemic effect is commonly 0. The organic solvents used in the study were of analytical grade. Wichterle and D. Jul 1, 2020 · Poloxamer enhances cerebral blood flow through improved rheology and the anti-inflammatory effect of poloxamer decrease the lesion size [200]. Indian Chemical Company - Offering Poloxamer 407, BASF, 25 Kgs at Rs 1500 in New Delhi, Delhi. A small peak eluting after the large peak was also observed in the poloxamer 407 chromatogram as a result of the bimodal distribution of poloxamers. It is freely soluble in ethanol, freely soluble in water (opalescent solution), and is insoluble in diethyl ether, paraffin and fatty oils. First-aid measures Description of first aid measures Inhalation Remove to fresh air. This research grade product is intended for use in R&D and development only. Kolliphor® P 188 Cell Culture is supplied as white to slightly yellowish, coarse grained powder with a waxy consistency. This ingredient is also used as a thickener, gelling agent, co-emulsifier and bodying agent in toothpastes, mouthwashes, creams and liquid emulsions. Sep 12, 2018 · Poloxamer 407, also known by the trademark Pluronic® F127, is a water-soluble, non-ionic triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) between the two hydrophilic units of polyoxyethylene (POE). Poloxamer 188 at levels up to 7. It is used as an emulsifier, solubilizer, dispersing and wetting agent in the preparation of solid dispersions, and for the enhancement of the bioavailability of The Poloxamer 407 grades are poloxamers from the extensive line of Pluronic ® block copolymers. It is a tri-block co-polymer of propylene oxide and ethylene oxide Sep 12, 2018 · Poloxamer 407, also known by the trademark Pluronic ® F127, is a water-soluble, non-ionic triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) between the two hydrophilic units of polyoxyethylene (POE). Louis, MO, USA). Share On Facebook. Nov 25, 2023 · Poloxamer 407 aqueous solutions remain fluid below Tsol-gel and above this temperature turn to a semi-solid (Dumortier et al. As mentioned above, the addition of “a suitable antioxidant” is allowed according to USP and EP monographs ( Deutscher Apotheker Verlag, 2020 Nov 27, 2021 · Poloxamer 407 was manufactured by BASF (Ludwigshafen, Germany) under the trade name Pluronic ® F-127 and sold by Sigma-Aldrich as a “BioReagent, suitable for cell culture” grade, containing 100 ppm butylated hydroxytoluene by declaration; we used it without further purification. Jan 1, 2013 · Methods: Poloxamer 407, a thermosensitive polymer along with hydroxypropyl methylcellulose (HPMC E 15), were used as gelling agents; the formulations with poloxamer (16% w/v) and HPMC E15 (1 and 1 . Request Information - Investigating the tunability of Poloxamer 407 and Poloxamer 338 Gels Article Please use the form below to request a wide range of information, including brochures, white papers and articles. Keeping in view the above considerations, the prime objective of this study was to develop Brij-35 and poloxamer 407 based as well as mixed oral niosomes (based on Brij-35 and poloxamer 407) loaded with TLM for dissolution enhancement and to increase potential oral bioavailability. 2018 Version: 1. For certain active substances such as nifedipine, naproxen and fenticonazole as well as for essential In solid dispersions Kolliphor ® P 407 can be used in physical mixing, melt granulation, spray drying and hot melt extrusion processes. : HY-D1005 CAS No. Tên sản phẩm: Poloxamer 407 (Poloxamer F127), Pluracare® F127 NF Nguồn gốc: BASF (Đức) Poloxamer là một chất đồng trùng hợp khối polyoxyetylen polyoxypropylen ete với tên thương mại là Pluronic. PXM-188 is an ABA block type copolymer which contains around 80% POE units and 20% PPO units. The gel structure behaves as a barrier to drug Mar 25, 2017 · Poloxamer 407 with a nominal molar mass of 12,935 g/mol and an average composition of (EO) 106-(PO) 61-(EO) 106 was donated by BASF Chemtrade GmbH, Germany. 1 General. It contains polyethylene oxide-polypropylene oxide arranged in a triblock structure to form PEO-PPO-PEO symmetric. BASF poloxamer p 407 Poloxamer P 407, supplied by BASF, used in various techniques. Each molecule has a central hydrophobic PPO block and two hydrophilic PEO on both sides, of which polyethylene accounts for 70%. In this work, a precipitation inhibitor-based self-nanoemulsifying drug delivery system (PI-SNEDDS) was developed by employing Soluplus and Poloxamer 407 to improve drug dissolution and to inhibit drug precipitation in the gastrointestinal tract. Brij-35, poloxamer 407, and a combination of both. Kolliphor® P 407 micro Geismar BASF is committed to providing the poloxamer Kolliphor P188 Bio, which is designed to meet our partners’ needs in quality Jan 1, 2007 · The most widely used poloxamers in pharmaceutical preparations are poloxamer 407 (Pluronic ® F127, BASF) and poloxamer 188, due to their unique characteristics, including a high solubilizing Only monographed poloxamer that is liquid at room temperature Ideal for liquid dosage forms It has melting point around 16°C and hydrophiilic-lipophilic balance (HLB) value between 12-18 Aug 12, 2021 · 2. Micelles of Poloxamer 407 will have Tên sản phẩm: Poloxamer 407 (Poloxamer F127), Pluracare® F127 NF Nguồn gốc: BASF (Đức) Poloxamer là một chất đồng trùng hợp khối polyoxyetylen polyoxypropylen ete với tên thương mại là Pluronic. It is mainly used Sep 26, 2023 · Poloxamer 407. It offers effective content uniformity, solubilization and increase oral bioavailability of bioactive. Currently, excipient-grade poloxamer 188 NF, marketed by BASF under the Kolliphor® P188 brand, is a polymer used in a variety of pharmaceutical and biological applications, such as a shear protectant in cell culture production. It possesses solubilizing, bodying and gelling properties. 5Y1 g/kg IP. HLB value between 18-23. , USP / NF, JP: Poloxamer 407 25 Sep 26, 2023 · Poloxamer 407. The skin acts as a wall between the organism and the exterior milieu to protect the underlying organs, perform physiological functions necessary for survival, and resist external pathogens given its constant exposure to potential injury in daily life (Proksch et al. PLURACARE® F127 finds application in toothpaste, whitening gels, mouthwash, sun and skin care applications. Aug 1, 2019 · Poloxamer 407 (P407) and poloxamer 188 (P188) are among the most commonly used poloxamers in ocular drug delivery as a result of their good solubility in water, clarity of their aqueous solutions, concentration-dependent viscosity, shear-thinning behaviour of their aqueous solutions, and their safety to the ocular tissues. css"> <link rel="stylesheet" href="atoms-core. Kolliphor® P407 (Polyethylene-polypropylene glycol) is a cGMP Pharmaceutical Grade poloxamer suitable for a broad range of applications. PLURACARE® F 127 PRILL by BASF is a non-ionic surfactant and solubilizer. 1 * *The exact percentage (concentration) of composition has been withheld as a trade secret. PLURACARE® F 127 NF by BASF is a surfactant and emulsifier. haa ubdjh frx rjgv qqm dhykk dlcz oexzh ekyvc mdybm